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DoW Breast Cancer, Breakthrough Award Levels 1 and 2

Updated

Grant from the Defense Health Agency Contracting Activity - DHACA, open to any type of applicant. Closes Nov 18, 2026, 29 days left.

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Opportunity numberHT942526BCRPBTA122
AgencyDefense Health Agency Contracting Activity - DHACA
Funding typeGrant
FieldScience, technology and other research and development
Expected number of awards6
Total program funding$10.6 million
Cost sharing or matchingNot required
Assistance listing12.420
PostedSep 3, 2026
ClosesNov 18, 2026 (29 days left)
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Who can apply

Description

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Breakthrough Award mechanism supports promising research with high potential to lead to or make breakthroughs in breast cancer. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception. Applications must address the challenge in a way that can lead to a breakthrough and have major impact.

The FY26 Breakthrough Award mechanism contains four different funding levels designed to support major (but not all) stages of research that will lead to clinical application. Each level specifies a distinct research scope. This program announcement discusses the Breakthrough Award Levels 1 and 2.Distinctive Features:* This funding mechanism allows for applications submitted under Funding Level 1 or Funding Level 2.

Funding Level 2 also includes a Population Science Studies option. With compelling justification, population science studies may request higher levels of funding and an additional year in the period of performance.* This funding mechanism allows for a single Principal Investigator (PI), or two partnering PIs referred to as the Initiating PI and the Partnering PI. For the Partnering PI Option (PPIO), only the Initiating PI will submit a pre-application, but both PIs will need to submit at the full application stage.

Be advised, failure to submit all associated (Initiating and Partnering PI) applications by the deadline may result in administrative withdrawal.

Full announcement and how to apply on Grants.gov

Science, technology and other research and development grants right now

There are 99 open federal grants in science, technology and other research and development that small businesses may apply for; 46 close within 30 days. The median award ceiling is $1.2 million. The agencies offering the most are Defense Health Agency Contracting Activity - DHACA, U.S. National Science Foundation and National Institute of Justice. Grants in this field stay open a median of 154 days; this one is open for 76 days.

Who has won this program before

The largest grants and cooperative agreements under assistance listing 12.420 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.

Other open grants in the same program

Under assistance listing 12.420, the federal program this grant is paid from.

DoW Military Burn, Discovery Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 21, 2026 · 1 day left
Grant · Open to any applicant · HT942526MBRPDA
DoW Military Burn, Patient-Centered Research Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 21, 2026 · 1 day left
Cooperative agreement or Grant · Open to any applicant · HT942526MBRPPCRA
DoW Military Burn, Technology/Therapeutic Development Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 21, 2026 · 1 day left
Cooperative agreement or Grant · Open to any applicant · HT942526MBRPTTDA
DoW Arthritis Clinical Research Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 22, 2026 · 2 days left
Grant · Open to any applicant · HT942526ATRPCRA
DoW Arthritis Translational Research Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 22, 2026 · 2 days left
Grant · Open to any applicant · HT942526ATRPTRA

More open grants from the Defense Health Agency Contracting Activity - DHACA

38 open grants from this agency accept small businesses, with $183.2 million in total program funding listed.

DoW Autism Career Development Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 22, 2026 · 2 days left
Grant · Open to any applicant · HT942526ARPCDA
DoW Autism Clinical Trial Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 22, 2026 · 2 days left
Grant · Open to any applicant · HT942526ARPCTA
DoW Autism Idea Development Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 22, 2026 · 2 days left
Grant · Open to any applicant · HT942526ARPIDA
DoW Tick-Borne Disease Idea Development Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 22, 2026 · 2 days left
Grant · Open to any applicant · HT942526TBDRPIDA
DoW Tick-Borne Disease Therapeutic/Diagnostic Research Award
Defense Health Agency Contracting Activity - DHACA
Closes Oct 22, 2026 · 2 days left
Grant · Open to any applicant · HT942526TBDRPTDRA

All open federal grants for small businesses