Bid document

DARPA-SN-27-01

Special Notice
Protein Palace Proposers Day

DARPA-SN-27-01

October 22, 2026

Defense Advanced Research Projects Agency
Multi X Office
675 North Randolph Street
Arlington, VA 22203-2114

DARPA-SN-27-01

Proposers Day
Special Notice DARPA-SN-27-01
Protein Palace
Defense Advanced Research Projects Agency (DARPA)
Multi X Office (MXO)
Posting Date: October 22, 2026
Event Date: November 17, 2026, at 9:00 a.m. Eastern Time (ET) Registration Deadline: November 9, 2026, at 4:00 p.m. Eastern Time (ET) Location: Executive Conference Center, 4075 Wilson Blvd Ste 300, Arlington, VA 22203 Registration Website: Website Link
Technical POC: Dr. Huanan Zhang, MXO Program Manager
E-mail: [email protected]

PROPOSERS DAY DESCRIPTION:

The Defense Advanced Research Projects Agency (DARPA) will host an in-person Proposers Day in support of the Protein Palace program on November 17, 2026, at the Executive Conference Center, 4075 Wilson Blvd Ste 300, Arlington, VA 22203, from 9:00 a.m. to 4:00 p.m. ET. DARPA anticipates releasing the Protein Palace solicitation prior to Proposers Day. If released, the Protein Palace solicitation will be made available at https://sam.gov/.
The goals of the Proposers Day are:
(1) To introduce the science and technology community (industry, academia, and government) to the Protein Palace program vision and goals;
(2) To facilitate interaction between researchers with capabilities and interests relevant to the Protein Palace program goals;
(3) To collect questions during the event that DARPA may answer and make available in a Question and Answer document maintained at https://www.darpa.mil/research/programs/protein-palace and (4) To encourage and promote teaming arrangements among organizations that have the relevant expertise, research facilities, and capabilities for executing research and development responsive to the Protein Palace program goals.
The Proposers Day will include overview presentations by government personnel and opportunities for team building among the participants. It is anticipated that recording of the Proposers Day and materials will be posted online at https://www.darpa.mil/research/programs/protein-palace.

PROGRAM OBJECTIVE AND DESCRIPTION:

The objective of the Protein Palace program is to enable the rapid purification of virtually any protein with high specificity, purity, and yield. To achieve this goal, Protein Palace will break the traditional tradeoff between generalizability and specificity by leveraging dynamic chemical and physical approaches that probe