Bid document
Updated
A PDF document (960 KB) attached to High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE), from the Defense Advanced Research Projects Agency (DARPA). Due Nov 5, 2026.
File name: DARPA-PA-27-01.pdf
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Program Announcement (PA)
High-throughput Unmasking of Biological
Interactomes with Binding Landscape Emulators
(HUBBLE)
BIOLOGICAL TECHNOLOGIES OFFICE
DARPA-PA-27-01
October 08, 2026
RE: Program Announcement No. DARPA-PA-27-01 - HUBBLE
PROGRAM ANNOUNCEMENT OVERVIEW
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Federal Agency Name – Defense Advanced Research Projects Agency (DARPA), Biological Technologies Office (BTO)
Funding Opportunity Title – High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)
Announcement Type – Initial Announcement
Funding Opportunity Number – DARPA-PA-27-01
Dates
o Posting Date: October 8th, 2026
o Industry Day: September 25th, 2026
https://sam.gov/workspace/contract/opp/db09554820024ba29b5eac591030ac22/vi ewQuestions Due Date: November 3rd, 2026
o Abstract Due Date and Time: November 5th, 2026, 3:00 PM ET o Oral Proposal Package (OPP) Due Date and Time: December 11th, 2026, 3:00 PM ET
Description of the funding Opportunity: The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.
Multiple awards are anticipated.
Types of instruments that may be awarded – Other Transaction for Research Technical Point of Contact – Dr. Abhishek Singharoy, DARPA/BTO Agency Contact
The PA Coordinator for this effort can be reached at:
[email protected]
DARPA/BTO
ATTN: DARPA-PA-27-01
675 North Randolph Street
Arlington, VA 22203-2114
Attachments
A. Abstract Template and Instructions
B. Model Other Transaction (OT) for Research
C. Cost Proposal Spreadsheet
D. Schedule of Milestones and Payments
E. Task Description Document
F. Risk Matrix
RE: Program Announcement No. DARPA-PA-27-01 - HUBBLE
PROGRAM ANNOUNCEMENT
Defense Advanced Research Projects Agency (DARPA)
1. FUNDING OPPORTUNITY DESCRIPTION
1.1. Background
For decades, the DoW has confronted a broad spectrum of “diseases of the mind”, ranging from chronic neuropsychiatric conditions, like combat-related Post-Traumatic Stress Disorder and severe depression, to insidious neurodegenerative declines such as those triggered by Traumatic Brain Injury (TBI). Each of these conditions directly degrades operational readiness of the warfighter. Historically, military medicine has been forced to manage these complex cognitive and
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