SPECTRA ISO Amendment 2
Updated
A PDF document (697 KB) attached to Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA), from the National Institutes of Health. Due Dec 2, 2026, 3:00 PM (UTC-5).
File name: SPECTRA ISO ARPA-H-SOL-26-163 Amendment 2.pdf
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Innovative Solutions Opening (ISO)
Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA)
Proactive Health Office (PHO)
Advanced Research Projects Agency for Health
ARPA-H-SOL-26-163
October 29, 2026
SPECTRA ISO Amendment Log:
Amendment 1 (10/14/26): Updated Solution Summary due dates and timelines for all TAs. Amendment 2 (10/29/26): modifies the solicitation as follows: •
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Part I: Overview & Program Description
o Section 1.1 Program Summary: Added a “A note on continuity of care and participant commitments”.
Part II: Technical Areas & Requirements
o TA1: Makes various edits for clarification but no substantive changes. o TA2: Various edits for clarity including (1) responsibilities for the proposer versus the Government in required deliverables, (2) definition of a “node” for TA2, (3) adds a summary of TA2 technical requirements, (4) adds a summary of the TA2 phases, and (5) revises the table in TA2 Graded Performance Metrics.
o TA4: Modifies the TA4 Grade Performance Metrics to provide instructions for proposer-defined performance metrics.
Part III: Program Structure and Schedule
o Meetings & Required Travel: Provides additional information on program-required meetings and travel.
Part VI: General Information
o Questions and Answers: Added link to the publicly posted SPECTRA
FAQs
Provides Attachment B1 for TA4 Proposal Requirements and Proposal Volume Templates.
Provides Attachment A2 for TA1 Solution Summary Requirements and Attachment A3 for TA2 Solution Summary Requirements.
2.1.4 Technical Area 4 (TA4): Technologies for Communication, Quality of Life, and Embedded
INNOVATIVE SOLUTIONS OPENING (ISO)
Federal Agency: Advanced Research Projects Agency for Health (ARPA-H) Proactive Health Office (PHO)
Program Title: Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency
(SPECTRA)
Announcement Type: Solicitation
ISO Solicitation Number: ARPA-H-SOL-26-163
Issue Date: September 17, 2026
Solution Summary Submission Deadline:
TA 4: October 21, 2026 at 3pm ET (submission portal opens Oct 4, 2026) TA 1 and TA 2: December 2, 2026 at 3pm ET (submission portal opens Nov 18, 2026) TA 3: January 19, 2027 at 5pm ET (submission portal opens Jan 4, 2027) •
Anticipated ISO Amendment early Dec
Proposal deadline information for TA4 is in Attachment B1 (TA4 Proposal Requirements) in the ISO amendment posted October 29. TA1-3 proposal deadline information will be forthcoming.
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