BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Jan 28, 2027, 100 days left.

Opportunity number	RFA-NS-24-031
Agency	National Institutes of Health
Funding type	Grant
Field	Education, Health, Income security and social services
Award ceiling	$750,000
Cost sharing or matching	Not required
Assistance listing	93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867
Posted	Mar 19, 2024
Closes	Jan 28, 2027 (100 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Description

Awarded activities will facilitate the translation of novel recording and modulation technologies that can be used to treat and/or diagnose central nervous system (CNS) diseases and disorders and to better understand the human CNS, from proof of concept up to the stage of readiness for first in human (FIH) studies. Technologies may incorporate any signal modality (e.g., electrical, optical, magnetic, acoustic) or a combination thereof.

Diverse team-based applications that integrate appropriate domains of expertise are encouraged.

Full announcement and how to apply on Grants.gov

Education grants right now

There are 109 open federal grants in education that small businesses may apply for; 7 close within 30 days. The median award ceiling is $424,500; this grant offers up to $750,000. The agencies offering the most are National Institutes of Health and DOC NOAA - ERA Production. Grants in this field stay open a median of 1064 days; this one is open for 1045 days.

Who has won this program before

Yale Univ $67.5 million · from Jul 1, 2015
NEW York University $64.3 million · from Jul 7, 2010
University Of North Carolina AT Chapel Hill $49.7 million · from Jul 1, 2007
Baylor College Of Medicine $47.8 million · from Sep 28, 2011
Jackson Laboratory $47.2 million · from Sep 16, 2011

The largest grants and cooperative agreements under assistance listing 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.