National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Jan 7, 2027, 79 days left.

Opportunity number	PAR-25-081
Agency	National Institutes of Health
Funding type	Grant
Field	Education, Health
Award ceiling	$499,999
Total program funding	$499,999
Cost sharing or matching	Not required
Assistance listing	93.393, 93.394, 93.395, 93.399
Posted	Nov 12, 2024
Closes	Jan 7, 2027 (79 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Description

Through this Notice of Funding Opportunity, the National Cancer Institute (NCI) seeks research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM. The proposed project must involve at least 1 clinical trial related to the scientific interests of one or more of the following research programs: Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program and/or the HIV and AIDS Malignancies Research Programs.

Applicants may propose to conduct an early phase trial by itself, or in combination with another research aim(s) as appropriate.

Full announcement and how to apply on Grants.gov

Education grants right now

There are 109 open federal grants in education that small businesses may apply for; 7 close within 30 days. The median award ceiling is $424,500; this grant offers up to $499,999. The agencies offering the most are National Institutes of Health and DOC NOAA - ERA Production. Grants in this field stay open a median of 1064 days; this one is open for 786 days.

Who has won this program before

Ecog-Acrin Medical Research Foundation, Inc. $199.7 million · from Aug 1, 2014
American College Of Radiology $115.5 million · from May 26, 2014
The Regents Of The University Of Colorado $82.6 million · from Apr 4, 1997
Albert Einstein College Of Medicine $75.9 million · from Jun 1, 1997
The Regents Of The University Of California $60.2 million · from Sep 27, 2001

The largest grants and cooperative agreements under assistance listing 93.393, 93.394, 93.395, 93.399 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.