NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

Updated Oct 20, 2026

Cooperative agreement from the National Institutes of Health, open to small businesses. Closes Jul 5, 2029, 989 days left.

Opportunity number	PAR-27-058
Agency	National Institutes of Health
Funding type	Cooperative agreement
Field	Health
Award ceiling	$500,000
Cost sharing or matching	Not required
Assistance listing	93.121
Posted	Jun 16, 2026
Closes	Jul 5, 2029 (989 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Description

This Notice of Funding Opportunity (NOFO) will support, through the cooperative agreement mechanism, investigator-initiated observational studies or biomarker validation studies that require prospective collection of data/biospecimens or continued analysis of data/biospecimens.

Full announcement and how to apply on Grants.gov

Health grants right now

There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000; this grant offers up to $500,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 1115 days.

Who has won this program before

Fred Hutchinson Cancer Center $443.7 million · from Jun 29, 2006
University Of Washington $83.6 million · from Mar 1, 1997
Regents Of The University Of California, SAN Francisco, The $82.5 million · from Mar 1, 1997
President And Fellows Of Harvard College $76.7 million · from Jul 1, 2004
University Of Alabama AT Birmingham $69.9 million · from Mar 30, 1988

The largest grants and cooperative agreements under assistance listing 93.121 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.