Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Sep 28, 2028, 709 days left.

Opportunity number	RFA-OD-25-010
Agency	National Institutes of Health
Funding type	Grant
Field	Health
Expected number of awards	6
Total program funding	$5.0 million
Cost sharing or matching	Not required
Assistance listing	93.351
Posted	Dec 5, 2025
Closes	Sep 28, 2028 (709 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Refer to Section III. Eligibility Information of the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Description

The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP"s NIH-wide mission and programs.

Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted.

Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).

Full announcement and how to apply on Grants.gov

Health grants right now

There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 1028 days.

Who has won this program before

Oregon Health & Science University $203.0 million · from May 1, 1997
University Of Washington $201.8 million · from Jun 10, 1997
University Of California, Davis $191.3 million · from May 1, 1997
Emory University $167.0 million · from May 1, 1997
University Of Wisconsin System $150.2 million · from Jun 10, 1997

The largest grants and cooperative agreements under assistance listing 93.351 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.