Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Jul 1, 2028, 620 days left.

Opportunity number	PAR-27-022
Agency	National Institutes of Health
Funding type	Grant
Field	Health
Award ceiling	$5.0 million
Award floor	$300,000
Cost sharing or matching	Not required
Assistance listing	93.310, 93.351, 93.855, 93.859, 93.866, 93.867
Posted	Jun 25, 2026
Closes	Jul 1, 2028 (620 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Description

This Notice of Funding Opportunity (NOFO) announces the restructured Shared Instrumentation Grant (SIG) Program that consolidates three existing shared-use instrumentation programs, i.e., the Shared Instrumentation Grant program, the High-End Instrumentation Grant program, and the Basic Instrumentation Grant program. The NOFO invites applications from groups of NIH-supported investigators to purchase or upgrade a single state-of-the-art commercially available instrument or an integrated instrumentation system.

The instruments purchased through the SIG Program are required to be optimally shared among the users to ensure efficient and cost-effective research operations, enable rigorous and reproducible measurements, and encourage collaborative research and benefit broad research communities at large. The minimum award is $300,000. There is no cap on the total cost of the instrument; however, the maximum award is $5,000,000.

Cost sharing is required for premium instruments or special use instruments.

Full announcement and how to apply on Grants.gov

Health grants right now

There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000; this grant offers up to $5.0 million. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 737 days.

Who has won this program before

University Of North Carolina AT Chapel Hill $977.0 million · from Jun 29, 2006
Fred Hutchinson Cancer Center $383.5 million · from Jun 29, 2006
Icahn School Of Medicine AT Mount Sinai $250.0 million · from Mar 1, 2006
Dana-Farber Cancer Institute, Inc. $235.8 million · from Dec 1, 1977
Oregon Health & Science University $203.0 million · from May 1, 1997

The largest grants and cooperative agreements under assistance listing 93.310, 93.351, 93.855, 93.859, 93.866, 93.867 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.