Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)
Updated
Cooperative agreement from the National Institutes of Health, open to small businesses. Closes Jan 29, 2027, 99 days left.
| Opportunity number | RFA-AI-28-012 |
|---|---|
| Agency | National Institutes of Health |
| Funding type | Cooperative agreement |
| Field | Health |
| Expected number of awards | 5 |
| Total program funding | $7.0 million |
| Cost sharing or matching | Not required |
| Assistance listing | 93.310, 93.855 |
| Posted | Oct 20, 2026 |
| Closes | Jan 29, 2027 (99 days left) |
| Add the deadline to | Google Calendar |
Who can apply
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Public housing authorities and Indian housing authorities
- Native American tribal organizations (other than federally recognized tribal governments)
- Nonprofits with 501(c)(3) status, other than institutions of higher education
- Nonprofits without 501(c)(3) status, other than institutions of higher education
- Private institutions of higher education
- For-profit organizations other than small businesses
- Small businesses
- Others (see the eligibility notes)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Description
The purpose of this notice of funding opportunity (NOFO) is to support a consortium of Translational Centers using Microphysiological Systems (MPS) for Infectious Diseases (TCMID). Recent efforts in the MPS fields are moving towards validation and regulatory use but have not focused upon models studying infectious diseases and testing of medical interventions. The NIH and FDA have recently issued guidance and established initiatives for enhancing use of New Approach Methodologies (NAMs) in research and product development.
This includes in vitro systems that allow scientists to model human disease and capture human variability and patient-specific characteristics that will accelerate safer treatments for patients while reducing costs and sparing use of laboratory animals. To meet this need, the Centers will refine well validated human tissue models studying infectious diseases to a level consistent with regulatory qualifications that will promote their adoption for use by product developers, supporting regulatory acceptance.
Full announcement and how to apply on Grants.gov
Health grants right now
There are 354 open federal grants in health that small businesses may apply for; 32 close within 30 days. The median award ceiling is $500,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1028 days; this one is open for 101 days.
Who has won this program before
- University Of North Carolina AT Chapel Hill $977.0 million · from Jun 29, 2006
- Fred Hutchinson Cancer Center $383.5 million · from Jun 29, 2006
- Icahn School Of Medicine AT Mount Sinai $250.0 million · from Mar 1, 2006
- Dana-Farber Cancer Institute, Inc. $235.8 million · from Dec 1, 1977
- Oregon Health & Science University $203.0 million · from May 1, 1997
The largest grants and cooperative agreements under assistance listing 93.310, 93.855 with funding activity since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.
Other open grants in the same program
Under assistance listing 93.310, 93.855, the federal program this grant is paid from.
More open grants from the National Institutes of Health
344 open grants from this agency accept small businesses, with $385.7 million in total program funding listed.