High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)
Updated
Solicitation from the Defense Advanced Research Projects Agency (DARPA). Due Nov 5, 2026, 7 days left.
| Solicitation number | DARPA-PA-27-01 |
|---|---|
| Agency | Defense Advanced Research Projects Agency (DARPA) |
| Office | Def Advanced Research Projects Agcy |
| Notice type | Solicitation |
| Set-aside | None |
| Trade (NAICS) | Research and Development in Biotechnology (except Nanobiotechnology) (541714) |
| Product or service code | AC12 |
| Posted | Oct 28, 2026 |
| Response deadline | Nov 5, 2026 (7 days left) |
| Add the deadline to | Google Calendar · Apple / Outlook (.ics) |
Bid documents (8)
- Attachment A Abstract Template and Instructions Phase 1 45 KB
- Attachment C Cost Proposal Spreadsheet HUBBLE 553 KB
- Attachment D Schedule Milestone and Payments 28 KB
- Attachment E Task Description Document HUBBLE 30 KB
- Attachment F Risk Matrix HUBBLE 89 KB
- Bid document 960 KB
- Attachment B Model OT for Research HUBBLE 117 KB
- Amendment 1 748 KB
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Description
UPDATE: The purpose of Amendment 1 to DARPA-PA-27-01, the HUBBLE Program Announcement (PA), is to update Attachment B and the verbiage in Section 4.1.2 and Section 7.8 of the Program Announcement. The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.
Contracting contact
- Dr. Abhishek Singharoy, DARPA/BTO · [email protected]
As published on the official notice. Ask questions in writing and before any questions deadline the notice sets.
Is your business small enough?
For NAICS 541714, a business counts as small if it has no more than 1,000 employees (SBA size standard, with exceptions in the notes). This notice is not set aside, but the size decides your small business status on it. SBA table, current as of Oct 15, 2026.
Notice history
- Oct 8, 2026: Solicitation Due Nov 5, 2026
Companies that win this kind of work
Federal contractors paid for research and development in biotechnology work, who also hold DARPA contracts (last 12 months): possible competitors, or partners to team with.
- The Charles Stark Draper Laboratory, Inc. $9.8 million in this trade
- Raytheon Company $6.7 million in this trade
- Regents Of The University Of Michigan $6.0 million in this trade
- The Johns Hopkins University Applied Physics Laboratory LLC $5.6 million in this trade
- The Johns Hopkins University $4.9 million in this trade
About the buyer
The Defense Advanced Research Projects Agency awarded $1.2 billion in contracts in the last 12 months; its biggest suppliers were Lockheed Martin Corporation, Securigence LLC and The Johns Hopkins University Applied Physics Laboratory LLC. See what DARPA is buying now.
Research and Development in Biotechnology contracts right now
There are 41 open government contract opportunities in this trade (NAICS 541714), 8 posted in the last 7 days; 46% are set aside for small businesses. The agencies buying the most are Defense Health Agency (DHA), Office of Assistant Secretary for Preparedness and Response and National Institutes of Health. Most of the work with a stated place is in Maryland, District of Columbia and New Mexico. A notice in this trade gives a median of 54 days from posting to deadline; this one gives 8 days.
All open research and development in biotechnology contracts
Coming up in this trade
Planned contracts from the agencies' procurement forecasts, often months before a solicitation. Plans can change.
Recent awards in this trade
- Red Duke Strategies LLC $1.5 million · Department of Veterans Affairs · Sep 23, 2026
- Reagan-Udall Foundation For The Food And Drug Administration, Inc. $1.2 million · Defense Advanced Research Projects Agency (DARPA) · Sep 14, 2026
From the award notices agencies publish.