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Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA)

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Solicitation from the National Institutes of Health. Due Dec 2, 2026, 3:00 PM (UTC-5), 22 days left.

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Solicitation numberARPA-H-SOL-26-163
AgencyNational Institutes of Health
OfficeAdvanced Research Projects Agency for Health (ARPA-H)
Notice typeSolicitation
Set-asideNone
Trade (NAICS)Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) (541715)
Product or service codeAN13
PostedNov 9, 2026
Response deadlineDec 2, 2026, 3:00 PM (UTC-5) (22 days left)
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Description

Amendment 3 (11/09/2026): ISO updates to Part II - Technical Areas & Requirements: TA1: Edits to the "Target" language for the Retrospective Data Access metric. Amendment 2 (10/29/2026): Numerous changes including, but not limited to,: ISO updates in Parts I, II, III and VI; TA1 clarifications; TA2 updates; TA4 updates; Q&A link added Provides Attachment B1 for TA4 Proposal Requirements and Proposal Volume Templates.

Provides Attachment A2 for TA1 Solution Summary Requirements and Attachment A3 for TA2 Solution Summary Requirements. Amendment 1 (10/14/2026): Update due dates and/or times of all TAs SPECTRA will identify and act on autism trajectories, the evolving developmental paths individuals follow across the lifespan from the prenatal period through aging, spanning autism characteristics, co-occurring conditions, and functional outcomes together with the genetic, biological, behavioral, iatrogenic (medical influences), environmental factors and their nonlinear interactions.

Rather than examining these factors in isolation, SPECTRA will examine how they combine and interact, including their nonlinear interactions, to produce autism and its co-occurring conditions over time. SPECTRA will also develop technologies that serve two purposes at once: extending reliable assessment beyond the clinic while improving everyday communication, function, and quality of life.

The same tools people use to live more fully will also generate the data that drive measurement and personalized care.

Contracting contact

As published on the official notice. Ask questions in writing and before any questions deadline the notice sets.

Is your business small enough?

For NAICS 541715, a business counts as small if it has no more than 11 employees (SBA size standard, with exceptions in the notes). This notice is not set aside, but the size decides your small business status on it. SBA table, current as of Oct 15, 2026.

Notice history

Companies that win this kind of work

Federal contractors paid for research and development in the physical, engineering, and life sciences work, who also hold NIH contracts (last 12 months): possible competitors, or partners to team with.

About the buyer

The National Institutes of Health awarded $5.9 billion in contracts in the last 12 months; its biggest suppliers were Leidos Biomedical Research Inc, M. A. Mortenson Company and Deloitte Consulting LLP. See what NIH is buying now.

Research and Development in the Physical, Engineering, and Life Sciences contracts right now

There are 262 open government contract opportunities in this trade (NAICS 541715), 32 posted in the last 7 days; 29% are set aside for small businesses. The agencies buying the most are Department of the Air Force, Department of the Army and Defense Advanced Research Projects Agency (DARPA). Most of the work with a stated place is in Maryland, District of Columbia and Virginia. A notice in this trade gives a median of 63 days from posting to deadline; this one gives 23 days.

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