Amendment 3: Changes Table

Change History Table: Original – Amendments (3)

Amendment 3(Mar 29 2024): BARDA BAA-23-100-SOL-00004 List of Changes:

Amendment 3 (Mar 29, 2024)
1. Updates to Area of Interest #3: Antimicrobials
• Updated AOI 3.1. MDR Bacteria and Biothreat Pathogens • Updated 3.2. MDR Fungal Infections
2. Updates to Area of Interest #5: Chemical Medical Countermeasures • Updated AOI 5.2. Opioids and Other Respiratory Depressants • Updated TRL Requirement
3. Updates to Area of Interest #6: Burn and Blast Medical Countermeasures • Updated AOI 6.1. Enabling Technologies to Address General Burn & Blast Traumatic Injuries • Updated AOI 6.2. Management of Head Injuries in Trauma • Updated AOI 6.3. Hemorrhage Control
• Suspend AOI 6.4. Non-Autologous Topical Products to Prevent or Reduce Burn Wound Conversion • Added new AOI 6.5. Management of Blunt Trauma Injuries • Added new AOI 6.6. Advanced Imaging Technologies in Management of Trauma • Added new AOI 6.7. Special Instruction for health economic impact assessment of Burn MCMs • Added new AOI 6.8 Special Instruction for Platform Agnostic Software for AI Augmentation of Ultrasound Imaging Data. 4. Updates to Area of Interest #7: Diagnostics
• Updated AOI 7.1.3. Biothreat Agent Diagnostics: Filovirus Point-of-Care and Remote Settings • Updated AOI 7.2.1. Bacterial Antimicrobial Resistance (AMR) Testing Direct from Specimen • Suspend AOI 7.2.2. Bacterial vs. Viral Infections: Point-of-Care • Updated TRL Requirement

Amendment 2(Dec 22, 2023): BARDA BAA-23-100-SOL-00004 List of Changes: Amendment 2 (Dec 22, 2023)
1. Suspend AOI 9.4 COVID-19 Monoclonal Antibody Therapeutics for Treatment

Amendment 1(Nov 9, 2023): BARDA BAA-23-100-SOL-00004 List of Changes: Amendment 1 (Nov 9, 2023)

1. Updates to Overview Information –

• Updated Research and Development Opportunity Description • Updated General Market Research (TechWatch Program),
• Updated Application Process,
• Updated Contract and Submission Information,
• Updated Electronic Portal Submission Instructions

2. Updates to Background

3. Updates to Part I: Development and Technical Objectives 4. Updates to Part IV: Pre-Submission Call and Quad Chart/Market Research Abstract Instructions (Stages 1 & 2) • Updated Figure 1. BARDA BAA Process Flow Chart
• Updated Stage 1: Pre-submission Call with Technical POC 5. Updates to Part VI: Proposal Instructions (Stage 3)
• Updates to Stage 3: Proposal Precreation
o Section M. Past Performance Information &