Amendment 6: Changes Table

Change History Table: Original – Amendments (6)
Amendment 6 (May 29, 2025): BARDA BAA-23-100-SOL-00004 List of Changes: Amendment 6 (May 29, 2025)

1. Updates to Introduction

• Updated language under Introduction
• Added additional Disclaimer

2. Updates to Overview Information

• Updated language under Eligible Offerors

3. Updates to Background

• Updated language under Background
• Updated Table 2
4. Updates to Part I: Development and Technical Objectives • Updated language to Development and Manufacturing Approach 5. Updates to Part VI: Proposal Instructions (Stage 3) – Volume II – Cost Proposal Attachments • Rescinded Vol. II, Attachment 13: Procurements Involving Synthetic Nucleic Acid and Screening 6. Updates to Part VII: Proposal Evaluation
• Updated language under Program Relevance
• Added additional Other Evaluation Factors and Considerations for: i. Gain of Function Research
ii. Domestic Based Manufacturing
7. Updates to Part VII: Research and Development Areas of Interest • Added definitions
8. Updates to Area of Interest #1: CBRN Vaccines
• Updated language under introductory paragraph to AOI
• Updated AOI 1.2. Sudan Virus and Marburg Virus
• Updated AOI 1.3. Flexible Vaccine Manufacturing Platform Technologies • Updated AOI 2.2. Botulism Antitoxins
• Updated AOI 2.4. Filovirus Antivirals
9. Updates to Area of Interest #3: Antimicrobials
• Updated language under introductory paragraph to AOI

Amendment 6 (May 29, 2025)
• Updated AOI 3.1. MDR Bacteria and Biothreat Pathogens • Updated AOI 3.2. MDR Fungal Infections
• Updated language under Qualities That Strengthen the Competitiveness of a Proposal 10. Updates to Area of Interest #4: Radiological/Nuclear Threat Medical Countermeasures • Updated language under introductory paragraphs to AOI • Updated AOI 4.1. Acute Radiation Syndrome (ARS)
• Updated AOI 4.2. Uncontrolled Hemorrhage
• Updated AOI 4.3. Radiation Injury and Trauma Pathophysiologies • Updated AOI 4.4. Enabling Technologies and Platforms
• Suspend AOI 4.5. Decorporation Agents
• Updated language under Qualities That Strengthen the Competitiveness of a Proposal 11. Updates to Area of Interest #5: Chemical Medical Countermeasures • Updated language under Qualities That Strengthen the Competitiveness of a Proposal 12. Updates to Area of Interest #6: Burn and Blast Medical Countermeasures • Updated language under introductory paragraphs to AOI • Updated AOI 6.1. Burn and Blast Traumatic Injuries Management, including: