EHI ISO 2026 Amendment 1

ARPA-H-SOL-26-150, EHI

INNOVATIVE SOLUTIONS OPENING

FOR

EMERGING

HEALTH

INNOVATORS

EHI

OFFICE OF COMMERCIALIZATION

ARPA-H-SOL-26-150

September 15, 2026

ARPA-H-SOL-26-150, EHI

1.

1.1

1.2

2.

2.1

2.2

2.3

TOPIC 1: PRECISION CONTROL OF SKIN INFLAMMATION WITHOUT SYSTEMIC EXPOSURE 6

TOPIC 3: DEEP BRAIN STIMULATION FOR MECHANISTIC SLEEP EXPLORATION (DEEP

SLEEP)

TOPIC 4: CLEAR-MIND — RESTORING THE BRAIN’S DRAINAGE AND IMMUNE BALANCE TO

TOPIC 7: ENGINEERING DRT FOR PROGRAMMABLE DNA SYNTHESIS AS EMERGING NEW

TOPIC 8: PREVENTION OF LETHAL ALPHA-GAL ALLERGIC RESPONSES CAUSED

TOPIC 10: ENDING PREVENTABLE DEATHS FROM ECTOPIC PREGNANCY THROUGH

TOPIC 11: TRANSFORMING THE WELL-WOMAN EXAM THROUGH OBJECTIVE DATA . 16

TOPIC 12: INNOVATIONS IN BIOTRANSPORT TO SUPPORT LONG-TERM

TOPIC 13: ORGANS-IN-ACTION: NEXT-GENERATION HUMAN TISSUE PLATFORMS FOR

TOPIC 14: NEAR REAL-TIME, NON-CONTACT DETERMINATION OF STERILITY IN

TOPIC 15: ICAT (IN-CAVITY ADJUVANT THERAPY): IMPLANTABLE SYSTEMS FOR LOCAL

TOPIC 16: CAUSALLY-GROUNDED ALIGNMENT FOR CLINICAL GENERATIVE ARTIFICIAL

2.4

2.5

2.6

ARPA-H-SOL-26-150, EHI

2.7

3.

3.1

3.2

3.3

3.4

3.5

3.6

3.7

4.

4.1 CONTROLLED UNCLASSIFIED INFORMATION (CUI) ON NON-FEDERAL

4.2

4.3

4.4

4.5

4.6

4.7

4.8

4.9

ATTACHMENT A: Solution Summary Template
ATTACHMENT B: Pitch Slides Template
ATTACHMENT C: Technical and Management Proposal Template ATTACHMENT D: Task Description Document (TDD)
ATTACHMENT E: Milestone Payment Schedule Template
ATTACHMENT F: Administrative and National Policy Requirements Document Template ATTACHMENT G: ARPA-H Model Other Transaction (Provided for reference purposes only)

ARPA-H-SOL-26-150, EHI

FEDERAL AGENCY: Advanced Research Projects Agency for Health (ARPA-H) PROGRAM TITLE: Emerging Health Innovators (EHI) Initiative ANNOUNCEMENT TYPE: Solicitation

ISO SOLICITATION NUMBER: ARPA-H-SOL-26-150

DATES: (All times listed are Eastern Time)
•
•
•
•
•

Solution Summaries Due: October 30, 2026, 2:00 PM ET
Questions & Answers (Q&A) due date: February 3, 2027, 2:00 PM ET Full Proposals Due: February 10, 2027, 2:00 PM ET
Tentative Performer Selection Date: April 30, 2027
Tentative Award Start Date: June 30, 2027

ANTICIPATED AWARDS: Multiple Other Transaction (OT) Agreements AWARD AMOUNT: Each award consists of the following periods of performance and not to exceed (NTE) values. Total Award Value shall not exceed $1,050,000: o
o
o

Base Period Year 1 (12 Months):
$350,000 (NTE)
Base Period Year 2 (12 Months):
$350,000 (NTE)
Option Period Year 3 (12 Months): $350,000 (NTE)