Assessing the Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R33 Clinical Trial Required)
Updated
Grant from the National Institutes of Health, open to small businesses. Closes Nov 16, 2029, 1123 days left.
| Opportunity number | PAR-28-091 |
|---|---|
| Agency | National Institutes of Health |
| Funding type | Grant |
| Field | Health |
| Award ceiling | $500,000 |
| Cost sharing or matching | Not required |
| Assistance listing | 93.213, 93.473 |
| Posted | Oct 15, 2026 |
| Closes | Nov 16, 2029 (1123 days left) |
| Add the deadline to | Google Calendar |
Who can apply
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Public housing authorities and Indian housing authorities
- Native American tribal organizations (other than federally recognized tribal governments)
- Nonprofits with 501(c)(3) status, other than institutions of higher education
- Nonprofits without 501(c)(3) status, other than institutions of higher education
- Private institutions of higher education
- For-profit organizations other than small businesses
- Small businesses
- Others (see the eligibility notes)
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Description
The National Center for Complementary and Integrative Health (NCCIH) announces this Notice of Funding Opportunity (NOFO) to solicit applications for multi-site feasibility trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) to reproduce and translate mechanisms of emotional well-being (EWB) into large-scale clinical trials that advance our understanding of whole person health.
These early-phase multi-site trials are essential for
- demonstrating that the mind and body intervention can be delivered with fidelity across sites;
- demonstrating reproducibility and rigor in engaging targeted mechanisms of EWB by the mind and body intervention across sites;
- assessing feasibility of participant recruitment and retention, as well as randomization;
- assessing feasibility of collecting comprehensive clinical (whole person health restoration) and mechanistic (EWB) data across sites; and
- exploring correlations between changes in mechanistic targets and clinical outcome measurements pooled across sites.
By laying this groundwork, studies supported under this NOFO will advance the science of whole person health and prepare the field for rigorous clinical trials and mechanistic mediation analysis with the potential to improve the health and well-being of all Americans.
Full announcement and how to apply on Grants.gov
Health grants right now
There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000; this grant offers up to $500,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 1128 days.
Who has won this program before
- University Of Massachusetts Medical School $139.0 million · from Aug 22, 2018
- Baylor College Of Medicine $47.8 million · from Sep 28, 2011
- University Of California, LOS Angeles $36.7 million · from Sep 26, 2014
- President And Fellows Of Harvard College $27.9 million · from Apr 19, 2023
- Regents Of The University Of Minnesota $21.6 million · from Sep 23, 2022
The largest grants and cooperative agreements under assistance listing 93.213, 93.473 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.
Other open grants in the same program
Under assistance listing 93.213, 93.473, the federal program this grant is paid from.
More open grants from the National Institutes of Health
340 open grants from this agency accept small businesses, with $356.4 million in total program funding listed.