Bioengineering Research Grants (BRG) (R01 Clinical Trial Optional)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Jul 5, 2029, 989 days left.

Opportunity number	PAR-27-072
Agency	National Institutes of Health
Funding type	Grant
Field	Health
Award ceiling	$500,000
Cost sharing or matching	Not required
Assistance listing	93.393, 93.394, 93.395, 93.396, 93.399, 93.853, 93.865, 93.867
Posted	May 4, 2026
Closes	Jul 5, 2029 (989 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Description

This Notice of Funding Opportunity (NOFO) encourages collaborations between the life and physical sciences that:

apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and
integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, or clinical science and practice.

An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research and is appropriate for small teams applying an integrative approach to increase our understanding of and solve problems in biological, clinical, or translational science. This NOFO will support clinical trials that test functionality or validate performance in the chosen setting.

This NOFO is not intended to support conventional clinical trials that lack translation as the primary motivation. Applications that propose phase III clinical trials in any area of research are not sought by and will not be supported through this NOFO. This NOFO does not support commercial production.

Full announcement and how to apply on Grants.gov

Health grants right now

There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000; this grant offers up to $500,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 1158 days.

Who has won this program before

Ecog-Acrin Medical Research Foundation, Inc. $199.7 million · from Aug 1, 2014
American College Of Radiology $115.5 million · from May 26, 2014
The Regents Of The University Of Colorado $82.6 million · from Apr 4, 1997
Albert Einstein College Of Medicine $75.9 million · from Jun 1, 1997
The Regents Of The University Of California $60.2 million · from Sep 27, 2001

The largest grants and cooperative agreements under assistance listing 93.393, 93.394, 93.395, 93.396, 93.399, 93.853, 93.865, 93.867 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.