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Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

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Grant from the National Institutes of Health, open to small businesses. Closes Aug 11, 2027, 295 days left.

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Opportunity numberPAR-25-101
AgencyNational Institutes of Health
Funding typeGrant
FieldEducation, Health
Award ceiling$150,000
Total program funding$150,000
Cost sharing or matchingNot required
Assistance listing93.279
PostedDec 30, 2024
ClosesAug 11, 2027 (295 days left)
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Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Description

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research.

The proposed research should:

  1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or
  2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

Full announcement and how to apply on Grants.gov

Education grants right now

There are 109 open federal grants in education that small businesses may apply for; 7 close within 30 days. The median award ceiling is $424,500; this grant offers up to $150,000. The agencies offering the most are National Institutes of Health and DOC NOAA - ERA Production. Grants in this field stay open a median of 1064 days; this one is open for 954 days.

Who has won this program before

The largest grants and cooperative agreements under assistance listing 93.279 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.

Other open grants in the same program

Under assistance listing 93.279, the federal program this grant is paid from.

NIDA Mentored Clinical Scientist Development Program Award in Substance Use and Substance Use Disorder Research (K12 Clinical Trial Optional)
National Institutes of Health
Closes Nov 13, 2026 · 24 days left
Grant · Up to $750,000 an award · PAR-24-089
Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)
National Institutes of Health
Closes Nov 16, 2026 · 27 days left
Grant · Up to $50,000 an award · PAR-25-370
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)
National Institutes of Health
Closes Nov 18, 2026 · 29 days left
Grant · PAR-25-369
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)
National Institutes of Health
Closes Nov 18, 2026 · 29 days left
Grant · PAR-25-371
Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
National Institutes of Health
Closes Nov 24, 2026 · 35 days left
Grant · PA-23-317

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340 open grants from this agency accept small businesses, with $356.4 million in total program funding listed.

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All open federal grants for small businesses