Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
Updated
Cooperative agreement from the National Institutes of Health, open to small businesses. Closes Aug 21, 2028, 671 days left.
| Opportunity number | PAR-25-446 |
|---|---|
| Agency | National Institutes of Health |
| Funding type | Cooperative agreement |
| Field | Education, Health |
| Award ceiling | $3.0 million |
| Cost sharing or matching | Not required |
| Assistance listing | 93.279 |
| Posted | Sep 10, 2025 |
| Closes | Aug 21, 2028 (671 days left) |
| Add the deadline to | Google Calendar |
Who can apply
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Public housing authorities and Indian housing authorities
- Native American tribal organizations (other than federally recognized tribal governments)
- Nonprofits with 501(c)(3) status, other than institutions of higher education
- Nonprofits without 501(c)(3) status, other than institutions of higher education
- Private institutions of higher education
- For-profit organizations other than small businesses
- Small businesses
- Others (see the eligibility notes)
Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
Description
The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption.
This NOFO will utilize the UG3/UH3 activity code.
Full announcement and how to apply on Grants.gov
Education grants right now
There are 109 open federal grants in education that small businesses may apply for; 7 close within 30 days. The median award ceiling is $424,500; this grant offers up to $3.0 million. The agencies offering the most are National Institutes of Health and DOC NOAA - ERA Production. Grants in this field stay open a median of 1064 days; this one is open for 1076 days.
Who has won this program before
- University Of North Carolina AT Chapel Hill $977.0 million · from Jun 29, 2006
- Family Health International $719.4 million · from Jun 1, 2006
- Fred Hutchinson Cancer Center $204.4 million · from Jun 29, 2006
- Duke University $200.6 million · from Sep 21, 2016
- Duke University $139.8 million · from Jan 1, 2017
The largest grants and cooperative agreements under assistance listing 93.279 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.
Other open grants in the same program
Under assistance listing 93.279, the federal program this grant is paid from.
More open grants from the National Institutes of Health
340 open grants from this agency accept small businesses, with $356.4 million in total program funding listed.