Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)

Updated Oct 20, 2026

Cooperative agreement from the National Institutes of Health, open to small businesses. Closes Oct 19, 2027, 364 days left.

Opportunity number	RFA-CA-27-019
Agency	National Institutes of Health
Funding type	Cooperative agreement
Field	Health
Award ceiling	$300,000
Award floor	$50,000
Expected number of awards	5
Total program funding	$2.4 million
Cost sharing or matching	Not required
Assistance listing	93.393, 93.394, 93.395, 93.396, 93.399
Posted	May 21, 2026
Closes	Oct 19, 2027 (364 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Description

This Notice of Funding Opportunity (NOFO) solicits applications for the development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology.

As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Program, this NOFO is focused on early-stage development from prototyping to initial dissemination. Early-stage development is defined for the purpose of this NOFO as initial tool development or the significant modification of existing tools for new applications. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research.

In order to be successful, proposed development plans must have a clear rationale for why the proposed technology is needed and how it will benefit the cancer research field. In addition, mechanisms to solicit feedback from driving research projects and other users throughout the development process must be included.This NOFO encourages applications that involve the development of new, user-friendly informatics technologies that support a wide range of cancer research, including discovery biology, population studies, as well as clinical and translational research.

The emphasis is on uniqueness and potential impact on cancer research. In addition, all projects proposed in response to this NOFO must involve the following general attributes:Potential to advance driving cancer research projects and the cancer research field in generalNovel informatics capabilities for the targeted cancer research domainCompelling plans and processes for engaging end users to evaluate and apply the tool or resourceA realistic timeline and milestones for technology development

Full announcement and how to apply on Grants.gov

Health grants right now

There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000; this grant offers up to $300,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 516 days.

Who has won this program before

Ecog-Acrin Medical Research Foundation, Inc. $199.7 million · from Aug 1, 2014
American College Of Radiology $115.5 million · from May 26, 2014
The Regents Of The University Of Colorado $82.6 million · from Apr 4, 1997
Albert Einstein College Of Medicine $75.9 million · from Jun 1, 1997
The Regents Of The University Of California $60.2 million · from Sep 27, 2001

The largest grants and cooperative agreements under assistance listing 93.393, 93.394, 93.395, 93.396, 93.399 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.