Full-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 - Clinical Trial Required)
Updated
Grant from the National Institutes of Health, open to small businesses. Closes Oct 15, 2027, 360 days left.
| Opportunity number | PAR-25-177 |
|---|---|
| Agency | National Institutes of Health |
| Funding type | Grant |
| Field | Health |
| Cost sharing or matching | Not required |
| Assistance listing | 93.242 |
| Posted | Nov 26, 2024 |
| Closes | Oct 15, 2027 (360 days left) |
| Add the deadline to | Google Calendar |
Who can apply
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Public housing authorities and Indian housing authorities
- Native American tribal organizations (other than federally recognized tribal governments)
- Nonprofits with 501(c)(3) status, other than institutions of higher education
- Nonprofits without 501(c)(3) status, other than institutions of higher education
- Private institutions of higher education
- For-profit organizations other than small businesses
- Small businesses
- Others (see the eligibility notes)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description
Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions (R01 Clinical Trial Required). This NOFO is a key element of NIMHs set of NOFOs to support clinical trials research across the intervention development and testing pipeline. The NOFO supports (1) clinical trials to test the effectiveness of optimized therapeutic and preventive interventions for use in community and practice settings; and (2) clinical trials to evaluate the effectiveness of patient-, provider-, organizational-, or systems-level services interventions to improve access, continuity, quality, equity, and/or value of mental health services.
This NOFO is intended to support trials that: address a significant problem, such that the findings have potential to inform practice; are adequately powered to definitively answer the primary research question(s), with well-justified hypotheses supported by pilot data; and are designed to examine questions regarding mediators and moderators of effects. Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support effectiveness trials that explicitly address whether the intervention engages the target(s)/mechanism(s) presumed to underlie the intervention effects (i.e., the mechanism(s) that accounts for changes in clinical/functional outcomes, changes in provider behavior, improved access or continuity of services, etc.).
The collaborative R01 mechanism provides support for multisite trials when two or more sites are necessary for completion of the trial (e.g., to increase sample size, accelerate recruitment, or increase sample diversity and representation).
Full announcement and how to apply on Grants.gov
Health grants right now
There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 1053 days.
Who has won this program before
- University Of North Carolina AT Chapel Hill $977.0 million · from Jun 29, 2006
- The Johns Hopkins University $282.0 million · from Jun 29, 2006
- Rutgers, The State University $179.7 million · from Jul 1, 2003
- Salk Institute For Biological Studies, SAN Diego, California, The $92.4 million · from Sep 1, 2022
- Allen Institute $91.9 million · from Aug 22, 2022
The largest grants and cooperative agreements under assistance listing 93.242 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.
Other open grants in the same program
Under assistance listing 93.242, the federal program this grant is paid from.
More open grants from the National Institutes of Health
340 open grants from this agency accept small businesses, with $356.4 million in total program funding listed.