The Genesis Mission: Transforming Science and Energy with AI
Updated
Other from the Office of Science, open to any type of applicant. Closes Dec 17, 2026, 58 days left.
| Opportunity number | DE-FOA-0003612 |
|---|---|
| Agency | Office of Science |
| Funding type | Other |
| Field | Science, technology and other research and development |
| Award ceiling | $16.0 million |
| Award floor | $500,000 |
| Total program funding | $293.8 million |
| Cost sharing or matching | Required |
| Assistance listing | 81.049 |
| Posted | Mar 17, 2026 |
| Closes | Dec 17, 2026 (58 days left) |
| Add the deadline to | Google Calendar |
Who can apply
- Unrestricted: any type of applicant
Description
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks.
By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia.
The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud. DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.
Full announcement and how to apply on Grants.gov
Science, technology and other research and development grants right now
There are 99 open federal grants in science, technology and other research and development that small businesses may apply for; 46 close within 30 days. The median award ceiling is $1.2 million; this grant offers up to $16.0 million. The agencies offering the most are Defense Health Agency Contracting Activity - DHACA, U.S. National Science Foundation and National Institute of Justice. Grants in this field stay open a median of 154 days; this one is open for 275 days.
Who has won this program before
- General Atomics $1.3 billion · from Nov 1, 2003
- Michigan State University $396.7 million · from Jul 15, 2023
- University Of Wisconsin System $241.0 million · from Dec 1, 2017
- South Dakota Science & Technology Authority $237.1 million · from Sep 30, 2019
- University Of Illinois $211.0 million · from Dec 1, 2017
The largest grants and cooperative agreements under assistance listing 81.049 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.
Other open grants in the same program
Under assistance listing 81.049, the federal program this grant is paid from.