High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Mar 5, 2027, 136 days left.

Opportunity number	RFA-DA-25-060
Agency	National Institutes of Health
Funding type	Grant
Field	Education, Health
Award ceiling	$1.5 million
Cost sharing or matching	Not required
Assistance listing	93.279
Posted	Jan 17, 2024
Closes	Mar 5, 2027 (136 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Description

The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use.

This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.

Full announcement and how to apply on Grants.gov

Education grants right now

There are 109 open federal grants in education that small businesses may apply for; 7 close within 30 days. The median award ceiling is $424,500; this grant offers up to $1.5 million. The agencies offering the most are National Institutes of Health and DOC NOAA - ERA Production. Grants in this field stay open a median of 1064 days; this one is open for 1143 days.

Who has won this program before

University Of North Carolina AT Chapel Hill $977.0 million · from Jun 29, 2006
Family Health International $719.4 million · from Jun 1, 2006
Fred Hutchinson Cancer Center $204.4 million · from Jun 29, 2006
Duke University $200.6 million · from Sep 21, 2016
Duke University $139.8 million · from Jan 1, 2017

The largest grants and cooperative agreements under assistance listing 93.279 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.