Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional)
Updated
Grant from the National Institutes of Health, open to small businesses. Closes Jan 7, 2028, 444 days left.
| Opportunity number | PAR-25-227 |
|---|---|
| Agency | National Institutes of Health |
| Funding type | Grant |
| Field | Health, Income security and social services |
| Cost sharing or matching | Not required |
| Assistance listing | 93.865 |
| Posted | Nov 6, 2024 |
| Closes | Jan 7, 2028 (444 days left) |
| Add the deadline to | Google Calendar |
Who can apply
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Public housing authorities and Indian housing authorities
- Native American tribal organizations (other than federally recognized tribal governments)
- Nonprofits with 501(c)(3) status, other than institutions of higher education
- Nonprofits without 501(c)(3) status, other than institutions of higher education
- Private institutions of higher education
- For-profit organizations other than small businesses
- Small businesses
- Others (see the eligibility notes)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description
The purpose of this Notice of Funding Opportunity (NOFO) encourages applications that will expand knowledge of the natural history of disorders that currently are, or may become, part of statewide newborn screening programs. A comprehensive understanding of the natural history of a condition is necessary to facilitate appropriate interventions for infants identified by newborn screening.
Characterization of the sequence and timing of symptom development provides information crucial for developing targeted, age-appropriate treatments and for establishing a baseline against which to assess novel interventions. In addition, for some conditions, establishment of genotype-phenotype correlations may facilitate prediction of the clinical course; for others, identification of modifying genetic, epigenetic, or environmental factors may enhance understanding of clinical outcomes.
Comprehensive data on the natural history of a condition will facilitate the fields ability to:
- identify the underlying biological mechanisms;
- understand the genetic and clinical heterogeneity and phenotypic expression of the condition;
- improve diagnostic accuracy;
- facilitate clinical trials by providing comprehensive natural history data;
- prevent, manage, and treat symptoms and complications of the condition;
- furnish physicians and families with needed support and predictive information about the condition; and
- establish data collection systems or patient registries to collect longitudinal data (e.g., child/family outcomes following newborn screening).
Full announcement and how to apply on Grants.gov
Health grants right now
There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 1157 days.
Who has won this program before
- Fred Hutchinson Cancer Center $1.1 billion · from Jun 29, 2006
- Family Health International $719.4 million · from Jun 1, 2006
- The Johns Hopkins University $282.0 million · from Jun 29, 2006
- Duke University $200.6 million · from Sep 21, 2016
- President And Fellows Of Harvard College $155.6 million · from Jun 29, 2006
The largest grants and cooperative agreements under assistance listing 93.865 with funding activity since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.
Other open grants in the same program
Under assistance listing 93.865, the federal program this grant is paid from.
More open grants from the National Institutes of Health
340 open grants from this agency accept small businesses, with $356.4 million in total program funding listed.