Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Feb 10, 2027, 113 days left.

Opportunity number	RFA-DK-27-119
Agency	National Institutes of Health
Funding type	Grant
Field	Health
Award ceiling	$750,000
Expected number of awards	4
Total program funding	$4.8 million
Cost sharing or matching	Not required
Assistance listing	93.847
Posted	Jun 16, 2026
Closes	Feb 10, 2027 (113 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Only institutions at which there is a strong ongoing base of digestive and/or liver diseases-relevant research that relates to the proposed theme of the Center are eligible. The already funded research base must have at least $3 million per year in direct costs of supported research within a proposed theme area that is of primary interest to the NIDDK. These may be a mix of Federal and privately funded research awards or research career development awards. However, at least 30 percent of the total funding contributing to the research base must be secured from the NIDDK. Moreover, enough awards within the research base must be Federal to fulfill the requirement that each Biomedical Research Core must be utilized by a minimum of two federally funded Center members. Training grants, education grants, and fellowship awards are not considered part of the research base funding. Since "Facilities and Administration" costs vary considerably between institutions, these must not be included in the calculation of the research base.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Description

This Notice of Funding Opportunity (NOFO) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK. The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases within the NIDDK's mission.

DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner. Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of the NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding.

Full announcement and how to apply on Grants.gov

Health grants right now

There are 350 open federal grants in health that small businesses may apply for; 33 close within 30 days. The median award ceiling is $500,000; this grant offers up to $750,000. The agencies offering the most are National Institutes of Health, Centers for Disease Control and Prevention - ERA and Centers for Disease Control - NCBDDD. Grants in this field stay open a median of 1031 days; this one is open for 239 days.

Who has won this program before

Benaroya Research Institute AT Virginia Mason $444.8 million · from Feb 1, 2014
University Of South Florida $181.3 million · from Sep 30, 2015
Case Western Reserve University $97.6 million · from Sep 30, 2011
University Of Washington $83.6 million · from Mar 1, 1997
Regents Of The University Of California, SAN Francisco, The $82.5 million · from Mar 1, 1997

The largest grants and cooperative agreements under assistance listing 93.847 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.