Toward Translation of Nanotechnology Cancer Interventions (TTNCI; R01 Clinical Trial Not Allowed)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Nov 15, 2027, 391 days left.

Opportunity number	PAR-25-336
Agency	National Institutes of Health
Funding type	Grant
Field	Education, Health
Cost sharing or matching	Not required
Assistance listing	93.395
Posted	Dec 16, 2024
Closes	Nov 15, 2027 (391 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Description

Through this Notice of Funding Opportunity (NOFO), entitled "Toward Translation of Nanotechnology Cancer Interventions" (TTNCI), the National Cancer Institute (NCI) encourages applications for advanced pre-clinical research, supporting translation of nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards are designed to mature experimental nanomedicines relying on nanoparticles and nano-devices which demonstrate strong potential to improve cancer treatment effectiveness due to the combination of nanoparticle/nano-device structural design and/or therapeutic/diagnostic cargo which is delivered.

TTNCI awards are expected to enable further development of proposed nanotechnology-based interventions to the stage in which they could continue on a developmental path towards the NCI Experimental Therapeutics (NExT) and other NCI translational programs.

Full announcement and how to apply on Grants.gov

Education grants right now

There are 109 open federal grants in education that small businesses may apply for; 7 close within 30 days. The median award ceiling is $424,500. The agencies offering the most are National Institutes of Health and DOC NOAA - ERA Production. Grants in this field stay open a median of 1064 days; this one is open for 1064 days.

Who has won this program before

COG Research Foundation, LLC $362.1 million · from Apr 11, 2014
Sloan-Kettering Institute For Cancer Research $264.0 million · from Jan 20, 1997
Icahn School Of Medicine AT Mount Sinai $250.0 million · from Mar 1, 2006
Ecog-Acrin Medical Research Foundation, Inc. $199.7 million · from Aug 1, 2014
NRG Oncology Foundation Inc $193.6 million · from Apr 17, 2014

The largest grants and cooperative agreements under assistance listing 93.395 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.