Protein Palace Attachment G Task Description Document TDD Template

TASK DESCRIPTION DOCUMENT

For

PROTEIN Palace

By

<<PERFORMER>>

<<DATE>>

0339090Protein purification represents one of the most challenging chemical separation problems because the target protein exists at a very low concentration within a highly complex mixture of soluble and insoluble components. The current state of the art for protein purification is highly specific, relying on a lock-and-key, one protein, one ligand paradigm for product capture that involves several additional steps to remove impurities and host proteins from the mixture. The development of downstream processing methods can be lengthy with no guarantee of success. Conventional biochemical purification design assumes there is no universal means of protein purification today because of our inability to create highly specific and tunable systems for molecular separation. Protein Palace aims to break the tradeoff of specificity and generalizability and deliver a single unit and reconfigurable platform capable of purifying virtually any target protein on demand with high specificity, purity, and yield, ensuring timely DoW access to proteins for current and emerging applications. 020000Protein purification represents one of the most challenging chemical separation problems because the target protein exists at a very low concentration within a highly complex mixture of soluble and insoluble components. The current state of the art for protein purification is highly specific, relying on a lock-and-key, one protein, one ligand paradigm for product capture that involves several additional steps to remove impurities and host proteins from the mixture. The development of downstream processing methods can be lengthy with no guarantee of success. Conventional biochemical purification design assumes there is no universal means of protein purification today because of our inability to create highly specific and tunable systems for molecular separation. Protein Palace aims to break the tradeoff of specificity and generalizability and deliver a single unit and reconfigurable platform capable of purifying virtually any target protein on demand with high specificity, purity, and yield, ensuring timely DoW access to proteins for current and emerging applications. Program Background

Project Overview

This section is focused on defining the specific project and should include a description that aligns with the technical proposal. Though not meant to be extensive (usually two to three paragraphs will suffice), it should capture: (1) what is the project about; (2) why it matters; (3) goals and objectives; (4) Government and performer defined metrics.