Protein Palace Attachment J CUI Guild

Controlled Unclassified Information Guide

Program: (U) Protein Palace
Program Manager: Huanan Zhang
Program Security Officer: James Persons

Date: November 9, 2026
Version: 1.0

signed by
ZHANG.HU Digitally

ZHANG.HUANAN.16

ANAN.1640 40228845

Date: 2026.11.10
228845
14:42:05 -05'00'

Huanan Zhang
MXO Program Manager

signed by
PERSONS.JA Digitally

PERSONS.JAMES.K

MES.KENNET ENNETH.1214880993

Date: 2026.11.10
H.1214880993 13:56:10 -05'00'

James Persons
MXO Program Security Officer

DISTRIBUTION STATEMENT A

Approved for Public Release: Distribution Unlimited

FOREWORD

1. DESCRIPTION

2. AUTHORITY

3. DISTRIBUTION

GENERAL

1. PURPOSE

2. APPLICABILITY AND SCOPE

3. OFFICE OF PRIMARY RESPONSIBILITY

4. CONTROLLED UNCLASSIFIED INFORMATION (CUI) CHALLENGES

5. CUI CATEGORIES

6. EXPORT CONTROL RESTRICTED INFORMATION

7. DISCLOSURE OF CUI

8. CUI PROTECTION REQUIREMENTS

9. NOTIFICATION OF UNAUTHORIZED DISCLOSURE

10. INFORMATION PROTECTION GUIDANCE CHARTS

ii

DISTRIBUTION STATEMENT A

Approved for Public Release: Distribution Unlimited

FOREWORD

1. DESCRIPTION

The Protein Palace program will develop new methods to purify virtually any protein, enabling separation of large complex molecules from biomanufacturing feedstocks with high specificity, purity, and yield. Protein Palace technologies will inform development of a single unit and reconfigurable platform.
(U) Performer deliverables for the Protein Palace program in Phase 1 include a demonstration of separation of multiple proteins with less emphasis on the purity or yield. In Phase 2, the performers will demonstrate a more precise separation of the proteins, specifically showing a higher percentage of purity and yield within defined constraints for time and volume. Both phases will include the performers designing and developing hardware at the Unclassified and TRL 4 level, “Applied Research – Components Validated in Laboratory Environment”.

2. AUTHORITY

CUI elements referenced in this guide are under the authority of Executive Order 13556, Controlled Unclassified Information, November 4, 2010 (as amended) and in accordance with DoDI 5200.48, “Controlled Unclassified Information,” March 6, 2020.

3. DISTRIBUTION

Distribution is authorized for public release.

iii

DISTRIBUTION STATEMENT A

Approved for Public Release: Distribution Unlimited

1. PURPOSE

a.The purpose of this CUI guide is to ensure the protection of MXO information IAW DoDI 5200.48. MXO information must be controlled and stored consistently with