Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)

Updated Oct 20, 2026

Grant from the National Institutes of Health, open to small businesses. Closes Nov 16, 2027, 392 days left.

Opportunity number	PAR-25-068
Agency	National Institutes of Health
Funding type	Grant
Field	Food and nutrition, Health
Cost sharing or matching	Not required
Assistance listing	93.847
Posted	Jan 8, 2025
Closes	Nov 16, 2027 (392 days left)
Add the deadline to	Google Calendar

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and state controlled institutions of higher education
Native American tribal governments (federally recognized)
Public housing authorities and Indian housing authorities
Native American tribal organizations (other than federally recognized tribal governments)
Nonprofits with 501(c)(3) status, other than institutions of higher education
Nonprofits without 501(c)(3) status, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others (see the eligibility notes)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Description

This Notice of Funding Opportunity (NOFO) invites applications for innovative basic and translational pilot research projects within the mission of the NIDDK that are aligned with NIH HIV/AIDS research priorities. These priorities were most recently outlined by the NIH Office of AIDS Research (OAR) in NOT-20-018, UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding, scientific priorities.

Potential topics could address multiple overarching priorities. These include elucidation of unique pathophysiological mechanisms contributing to HIV comorbidities, coinfections, and complications (CCCs) affecting organs, tissues, and processes within the mission of the NIDDK. Likewise, interrogations into biological mechanisms underlying HIV reservoirs in NIDDK-relevant tissues are important for developing strategies for long-term viral suppression or eradication.

Finally, health-impeding social determinants of health may affect CCCs or viral reservoirs within NIDDK's mission through multiple pathways.

Full announcement and how to apply on Grants.gov

Food and nutrition grants right now

There are 30 open federal grants in food and nutrition that small businesses may apply for; 0 close within 30 days. The median award ceiling is $225,000. The agencies offering the most are National Institutes of Health, Food and Drug Administration and DOC NOAA - ERA Production. Grants in this field stay open a median of 1096 days; this one is open for 1042 days.

Who has won this program before

Benaroya Research Institute AT Virginia Mason $444.8 million · from Feb 1, 2014
University Of South Florida $181.3 million · from Sep 30, 2015
Case Western Reserve University $97.6 million · from Sep 30, 2011
University Of Washington $83.6 million · from Mar 1, 1997
Regents Of The University Of California, SAN Francisco, The $82.5 million · from Mar 1, 1997

The largest grants and cooperative agreements under assistance listing 93.847 with payments since Oct 1, 2025, from USAspending.gov. Amounts are each award's total.